Biotechnology Bulletin ›› 2024, Vol. 40 ›› Issue (7): 55-67.doi: 10.13560/j.cnki.biotech.bull.1985.2024-0033
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LONG Jing1,2(), CHEN Jing-min1,2, LIU Xiao1, ZHANG Yi-fan1, ZHOU Li-bin1,2(), DU Yan1,2()
Received:
2024-01-11
Online:
2024-07-26
Published:
2024-07-30
Contact:
ZHOU Li-bin, DU Yan
E-mail:longjing@impcas.ac.cn;libinzhou@impcas.ac.cn;duyan@impcas.ac.cn
LONG Jing, CHEN Jing-min, LIU Xiao, ZHANG Yi-fan, ZHOU Li-bin, DU Yan. Repair Mechanisms of DNA Double-strand Breaks and Their Roles in Heavy Ion Mutagenesis and Gene Editing in Plants[J]. Biotechnology Bulletin, 2024, 40(7): 55-67.
基因缩写名称 Abbreviation of gene name | 英文全称 Full name in English | 基因ID Gene ID | 功能 Function | 参考文献 Reference |
---|---|---|---|---|
MRE11 RAD50 NBS1 | meiotic recombination 11 radiation sensitive 50 nijmegen breakage syndrome 1 | At5g54260 At2g31970 At3g02680 | 形成MRE11-RAD50-NBS1复合物行使DNA结合、核酸酶激活和DSBs末端处理 | [ |
EXO1 | exonuclease 1 | At1g29630 | DSBs末端切除 | [ |
RPA1 RPA2 RPA3 | replication protein a1 replication protein a2 replication protein a3 | At2g06510 At2g24490 At3g52630 | ssDNA结合 | [ |
IDN2 | involved in de novo 2 | At3g48670 | RPA结合 | [ |
RAD51 | radiation sensitive 51 | At5g20850 | 链入侵 | [ |
RAD52-1 RAD52-1 | radiation sensitive 52-1 radiation sensitive 52-2 | At1g71310 At5g47870 | ssDNA结合和退火 | [ |
RAD54 | radiation sensitive 54 | At3g19210 | 同源DNA的搜索 | [ |
RAD51B RAD51C RAD51D | rad51 paralog b rad51 paralog c rad51 paralog d | At2g28560 At2g45280 At1g07745 | ssDNA结合和稳定核蛋白丝 | [ |
XRCC2 XRCC3 | x-ray repair cross complementing 2 x-ray repair cross complementing 3 | At5g64520 At5g54750 | ssDNA结合 | [ |
BRCA1 | breast cancer 1 | At4g21070 | 同源DNA的搜索 | [ |
BRCA2A BRCA2B | breast cancer 2a breast cancer 2b | At4g00020 At5g01630 | 同源DNA的搜索 | [ |
DMC1 | disrupted meiotic cDNA 1 | At3g22880 | 链入侵 | [ |
COM1 | compositum 1 | At3g52115 | 链交换 | [ |
RAD1 RAD10 | radiation sensitive 1 radiation sensitive 10 | At5g41150 At3g05210 | 互补链的修剪 | [ |
FANCM | fanconi anemia complementation group m | At1g35530 | D-Loop形成和单链退火延伸 | [ |
PAF1 | polymerase associated factor 1 | At1g79730 | DNA末端结合 | [ |
DDRM2 | DNA damage response mutants 2 | At4g02110 | 招募RAD51 | [ |
SMC5 SMC6A | structural maintenance of chromosomes 5 structural maintenance of chromosomes 6A | At5g15920 At5g07660 | 促进姐妹染色单体排列 | [ |
Table 1 Key factors of HR repair pathway in plants(Having Arabidopsis thaliana as an example)
基因缩写名称 Abbreviation of gene name | 英文全称 Full name in English | 基因ID Gene ID | 功能 Function | 参考文献 Reference |
---|---|---|---|---|
MRE11 RAD50 NBS1 | meiotic recombination 11 radiation sensitive 50 nijmegen breakage syndrome 1 | At5g54260 At2g31970 At3g02680 | 形成MRE11-RAD50-NBS1复合物行使DNA结合、核酸酶激活和DSBs末端处理 | [ |
EXO1 | exonuclease 1 | At1g29630 | DSBs末端切除 | [ |
RPA1 RPA2 RPA3 | replication protein a1 replication protein a2 replication protein a3 | At2g06510 At2g24490 At3g52630 | ssDNA结合 | [ |
IDN2 | involved in de novo 2 | At3g48670 | RPA结合 | [ |
RAD51 | radiation sensitive 51 | At5g20850 | 链入侵 | [ |
RAD52-1 RAD52-1 | radiation sensitive 52-1 radiation sensitive 52-2 | At1g71310 At5g47870 | ssDNA结合和退火 | [ |
RAD54 | radiation sensitive 54 | At3g19210 | 同源DNA的搜索 | [ |
RAD51B RAD51C RAD51D | rad51 paralog b rad51 paralog c rad51 paralog d | At2g28560 At2g45280 At1g07745 | ssDNA结合和稳定核蛋白丝 | [ |
XRCC2 XRCC3 | x-ray repair cross complementing 2 x-ray repair cross complementing 3 | At5g64520 At5g54750 | ssDNA结合 | [ |
BRCA1 | breast cancer 1 | At4g21070 | 同源DNA的搜索 | [ |
BRCA2A BRCA2B | breast cancer 2a breast cancer 2b | At4g00020 At5g01630 | 同源DNA的搜索 | [ |
DMC1 | disrupted meiotic cDNA 1 | At3g22880 | 链入侵 | [ |
COM1 | compositum 1 | At3g52115 | 链交换 | [ |
RAD1 RAD10 | radiation sensitive 1 radiation sensitive 10 | At5g41150 At3g05210 | 互补链的修剪 | [ |
FANCM | fanconi anemia complementation group m | At1g35530 | D-Loop形成和单链退火延伸 | [ |
PAF1 | polymerase associated factor 1 | At1g79730 | DNA末端结合 | [ |
DDRM2 | DNA damage response mutants 2 | At4g02110 | 招募RAD51 | [ |
SMC5 SMC6A | structural maintenance of chromosomes 5 structural maintenance of chromosomes 6A | At5g15920 At5g07660 | 促进姐妹染色单体排列 | [ |
基因缩写名称 Abbreviation of gene name | 英文全称 Full name in English | 基因ID Gene ID | 功能 Function | 参考文献 Reference |
---|---|---|---|---|
Ku70(XRCC6) Ku80(XRCC5) | X-ray repair cross complementing 6 X-ray repair cross complementing 5 | At1g16970 At1g48050 | 结合并保护DSBs末端 | [ |
Pol θ | DNA polymerase theta | At4g32700 | DNA聚合酶,DSBs末端加工 | [ |
MRE11 RAD50 NBS1 | Meiotic recombination 11 Radiation sensitive 50 Nijmegen breakage syndrome 1 | At5g54260 At2g31970 At3g02680 | 形成MRE11-RAD50-NBS1复合物行使 DNA结合、核酸酶激活和DSBs末端处理 | [ |
LIG1 | DNA ligase 1 | At1g08130 | ATP依赖性DNA连接酶 | [ |
LIG4 | DNA ligase 4 | At5g57160 | ATP依赖性DNA连接酶 | [ |
PARP1 PARP2 | Poly(ADP-Ribose)polymerase 1 Poly(ADP-Ribose)polymerase 2 | At2g31320 At4g02390 | DNA末端结合 | [ |
XRCC4 | X-ray repair cross complementing 4 | At3g23100 | 结合LIG4 | [ |
Pol λ | DNA polymerase lambda | At1g10520 | DNA聚合酶,DSBs末端加工 | [ |
COM1 | Compositum 1 | At3g52115 | 链交换反应 | [ |
Table 2 Key factors of the plant NHEJ repair pathway(Having Arabidopsis thaliana as an example)
基因缩写名称 Abbreviation of gene name | 英文全称 Full name in English | 基因ID Gene ID | 功能 Function | 参考文献 Reference |
---|---|---|---|---|
Ku70(XRCC6) Ku80(XRCC5) | X-ray repair cross complementing 6 X-ray repair cross complementing 5 | At1g16970 At1g48050 | 结合并保护DSBs末端 | [ |
Pol θ | DNA polymerase theta | At4g32700 | DNA聚合酶,DSBs末端加工 | [ |
MRE11 RAD50 NBS1 | Meiotic recombination 11 Radiation sensitive 50 Nijmegen breakage syndrome 1 | At5g54260 At2g31970 At3g02680 | 形成MRE11-RAD50-NBS1复合物行使 DNA结合、核酸酶激活和DSBs末端处理 | [ |
LIG1 | DNA ligase 1 | At1g08130 | ATP依赖性DNA连接酶 | [ |
LIG4 | DNA ligase 4 | At5g57160 | ATP依赖性DNA连接酶 | [ |
PARP1 PARP2 | Poly(ADP-Ribose)polymerase 1 Poly(ADP-Ribose)polymerase 2 | At2g31320 At4g02390 | DNA末端结合 | [ |
XRCC4 | X-ray repair cross complementing 4 | At3g23100 | 结合LIG4 | [ |
Pol λ | DNA polymerase lambda | At1g10520 | DNA聚合酶,DSBs末端加工 | [ |
COM1 | Compositum 1 | At3g52115 | 链交换反应 | [ |
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