Effect of Antimony on the Enzyme Activity of Danio rerio

doi:10.13560/j.cnki.biotech.bull.1985.2018-1084

Abstract

Abstract: We aim to study the changes of various enzymes’ activities in organisms under heavy metal antimony stress and to identify the response mechanism of organisms to antimony stress. The changes of different enzyme activities in zebrafish were explored at different concentrations of antimony solution（0,10,20,30,and 40 mg/L）and period（24,48,96,and 144 h）. The results showed that the concentration of alkaline phosphatase in zebrafish was not dependent on the concentration of antimony,while the other 7 enzymes were significantly inhibited. With the increase of antimony stressing time,the activities of adenosine triphosphate and catalase in zebrafish presented a trend of first decreasing and then increasing;the activities of peroxidase,superoxide dismutase,acetylcholinesterase,lactate dehydrogenase,and acid phosphatase showed a “zigzag” trend;while the activities of alkaline phosphatase showed a trend of first increasing and then decreasing. In conclusion,antimony significantly affects the free radical regulation,excitation conduction,energy metabolism,substance transport,body growth and immune defense in zebrafish.

Key words: zebrafish, antimony, toxicity, enzymatic activity

YUE Xin, YANG Ai-jiang, XU Peng, HU Xia, ZHU Huan-yi, BAO Xin. Effect of Antimony on the Enzyme Activity of Danio rerio[J]. Biotechnology Bulletin, 2019, 35(6): 99-106.

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