Application and Prospect of Synthetic Biology in Improving Intestinal Health

doi:10.13560/j.cnki.biotech.bull.1985.2017-0648

Abstract

Abstract:

Synthetic biology is a novel research field,and it is referred to design and construct new artificial biological pathways,organisms,devices or redesign natural biological systems. Synthetic biology could be used to rebuild the symbiotic bacterial strains in our gut,which may effectively improve the intestinal health status of the host by the targeted regulation of the intestinal flora or intestinal cell state. Due to the strong flexibility,a wide range of controllable targets,target specificity and few side effects of this method,it has been gradually applied in the treatment of intestinal diseases. We summarized the advances on synthetic biology in the following aspects,first,intestinal pathogens killing and intestinal microbiota balance maintaining;second,nutrient metabolism assisting and metabolic diseases curing;third,intestinal diseases diagnosing,tumor tissue locating and intestinal immune system regulating. Further we analyzed the advantages and issues while synthetic biology used in improving intestinal health,and based on which,we proposed the technological route and management system of “synthetic biology-based novel probiotics system to achieve personalized medical treatment of intestinal health”.

Key words: synthetic biology, gut microbiota, intestinal health, probiotics

DU Ruo-xi, GUO Ming-zhang, XIE Zi-xin, HE Xiao-yun, HUANG Kun-lun, XU Wen-tao. Application and Prospect of Synthetic Biology in Improving Intestinal Health[J]. Biotechnology Bulletin, 2018, 34(1): 49-59.

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