成纤维细胞生长因子5研究进展

doi:10.13560/j.cnki.biotech.bull.1985.2018-0622

摘要/Abstract

摘要： 成纤维细胞生长因子5（Fibroblasts growth factor 5,FGF5）是成纤维细胞生长因子家族（FGFs）的成员之一,具备多种生物学功能。目前的研究发现,FGF5在哺乳动物毛发周期性生长中起着重要作用,是生长期到退行期的关键信号分子,同时与动物肢体发育及人多形性胶质母细胞瘤、黑色素瘤、肝细胞癌、人类高血压的形成也有一定的联系。综述了近年来FGF5的相关生物学功能及其在疾病形成中的研究结果,以期为其在人类毛发生长、动物绒毛资源利用、肢体发育以及肿瘤诊治等领域中进一步的研究及合理开发利用提供理论依据。

关键词: 成纤维细胞生长因子5, 毛发生长, 肢体发育, 肿瘤, 高血压

Abstract: FGF5（fibroblast growth factor 5，FGF5）is a member of fibroblast growth factors（FGFs），which possesses a variety of biological functions. Previous studies have found that FGF5 plays an important role in the cyclical growth of mammalian hair and is a key signal molecule from anagen to catagen. FGF5 also involves in animal limb development，human glioblastoma multiforme，melanoma，hepatocellular carcinoma and hypertension. In this paper，we review the biological functions of FGF5 and the related research results in disease formation in recent years，aiming at providing theoretical basis for its further research and rational utilization in the fields of human hair growth，animal villus resources utilization，limb development，and tumor diagnosis and treatment.

Key words: FGF5, hair growth, limb development, tumor, hypertension

雷蕾, 包鹏甲, 梁春年, 褚敏, 阎萍. 成纤维细胞生长因子5研究进展[J]. 生物技术通报, 2019, 35(3): 144-150.

LEI Lei BAO, Peng-jia, LIANG Chun-nian, CHU Min, YAN Ping. Research Progress on Fibroblast Growth Factor 5[J]. Biotechnology Bulletin, 2019, 35(3): 144-150.

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