人类长链非编码RNA相关SNP鉴定与功能预测的研究进展

doi:10.13560/j.cnki.biotech.bull.1985.2015.11.002

摘要/Abstract

摘要： 长链非编码RNA(lncRNA)是一类长度大于200个核苷酸，且不表现出任何蛋白质编码潜能的RNA。最新研究表明，lncRNA广泛地参与动植物的生长发育及疾病的发生发展等各种生物学过程，具有类型多、数量大且作用范围广等特点。目前对于lncRNA的发现、预测方法、功能及与疾病的关系已有了一系列报道。主要对lncRNA相关SNP文献进行综述，并对lncRNA相关SNP的鉴定与功能预测方法进行介绍。对其中涉及的生物信息学方法及相应的数据库进行全面综述，旨在为lncRNA研究提供新的思路，对复杂疾病的预测、诊断和治疗提供新的依据。

关键词: 长链非编码RNA, 生物信息学, 单核苷酸多态性, 数据库

Abstract: Long non-coding RNA(lncRNA)is a class of RNA, whose length is greater than 200 nucleotides and it does not show any protein-coding potential. The latest research shows that lncRNA plays function widely in the development of plants and animals, as well as in various diseases. There have been a series of reports on the discovery, prediction method, function study of lncRNA. Here, we reviewed the study of lncRNA related SNPs, including their identification and functional prediction. A comprehensive review of the bioinformatics methods and databases about the lncRNA related SNP was provided. These reviews may help to provide a new point of view for lncRNA research and a hint for the prediction, diagnosis and treatment of complex diseases based on lncRNA.

Key words: long non-coding RNA, bioinformatics, single nucleotide polymorphism, database

龚静, 柳纯洁, 缪小平, 郭安源. 人类长链非编码RNA相关SNP鉴定与功能预测的研究进展[J]. 生物技术通报, 2015, 31(11): 27-34.

Gong Jing, Liu Chunjie, Miao Xiaoping, Guo Anyuan. Research Progress of the Human Long Non-coding RNA Related SNP Identification and Function Prediction[J]. Biotechnology Bulletin, 2015, 31(11): 27-34.

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