Advances on Applications of Synthetic Biology and Directed Evolution in Microbial Systems

doi:10.13560/j.cnki.biotech.bull.1985.2017.01.008

Abstract

Abstract: Nowadays,there are needs to engineer complex multi-genic traits in modern biotechnology applications;however,our capability to rationally engineer them is limited by the lack of knowledge on the genetic basis of complex phenotypes. Using synthetic biological measures,complex phenotypes can be engineered at the systems level,and via directed evolution strategies the whole biological system may be driven toward desired phenotypes without requiring the knowledge of the genetic basis of the targeted traits. The latest developments in the synthetic biology accelerate the directed evolution cycle,facilitating engineering of increasingly complex traits in biological systems. Herein,the recent advances on synthetic biology in directed evolution of complex traits in microbial systems are reviewed.

Key words: synthetic biology, microbial system, directed evolution, application

GUO Yuan, ZHAO Zhong-lin. Advances on Applications of Synthetic Biology and Directed Evolution in Microbial Systems[J]. Biotechnology Bulletin, 2017, 33(1): 76-82.

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