Research Progress on Functional Nucleic Acid Nanomachine Biosensors

doi:10.13560/j.cnki.biotech.bull.1985.2018-0397

Abstract

Abstract: Functional nucleic acid nanomachine is a nucleic acid assembly that is naturally or artificially designed and self-assembled by nucleic acid base sequence-specific interactions. The operation of a functional nucleic acid nanomachine can be activated by transforming its structure or conformation in two ways. One way is for the functional nucleic acid to interact with specific signal molecules to change its structure,and the other way is to change the conformation of the functional nucleic acid under the stimulation of the external environment（such as changing the pH,adding ions,irradiation with different light,etc.）. The current researches mainly include functional nucleic acid nanomachines mediated by G-quadruplex functional nucleic acid,aptamer functional nucleic acid,deoxyribozyme,and Holliday junction functional nucleic acid,as well as based on non-metallic,metallic materials,strand-displacement,click-response,triplex nucleic acid,pH-response,and light-induced. This paper reviews the specific operating mechanisms of these classic functional nucleic acid nanomachines,and discusses the practical significance and existing problems in the drug targeted delivery,bioimaging application research. Finally,the paper prospects the application of functional nucleic acid nanomachines and the challenges that may be encountered.

Key words: functional nucleic acid, nanomachine, biosensor, comment

ZHANG Qian, TIAN Jing-jing, LUO Yun-bo, XU Wen-tao. Research Progress on Functional Nucleic Acid Nanomachine Biosensors[J]. Biotechnology Bulletin, 2018, 34(9): 2-14.

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