Research Progress on Functional Nucleic Acid Biosensor Mediated by Isothermal Technology

doi:10.13560/j.cnki.biotech.bull.1985.2018-0574

Abstract

Abstract: With the development of society,food diversity,and food circulation,consumers’ attention to food safety is increasing,which makes the demands of detection technologies for food safety risk factors rise. Functional nucleic acids play an important role in the field of detection by forming specific spatial structures and playing a variety of functions besides storing genetic information. Functional nucleic acid biosensor is based on functional nucleic acid to recognize target,to amplify signal or to put out signal with high sensitivity,high specificity,time-saving,and low cost. In order to avoid the dependence on temperature-changing equipment and to conduct on-site detection,functional nucleic acid biosensor mediated by the isothermal technology develops rapidly. Compared with temperature-changing technology,isothermal technology does not need temperature-changing equipment and some of them can be carried out at room temperature,which reduces the cost of detection and shortens the detection time to some extent. According to the function of isothermal technology in functional nucleic acid biosensor,it can be divided into isothermal-mediated signal recognition technology,signal amplification technology and signal output technology. Isothermal technologies in functional nucleic acid biosensors are introduced from above three aspects in this review and prospects are also summarized from these three aspects.

Key words: isothermal technology, functional nucleic acid, biosensor

ZHANG Yuan, XIAO Bing, TIAN Jing-jing, XU Wen-tao. Research Progress on Functional Nucleic Acid Biosensor Mediated by Isothermal Technology[J]. Biotechnology Bulletin, 2018, 34(9): 29-38.

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