Research Progress on Methionine Regulating the Oxidative Stress of Livestock and Poultry

doi:10.13560/j.cnki.biotech.bull.1985.2020-0271

Abstract

Abstract:

Methionine is an essential amino acid for livestock and poultry,and has extensive and important biological functions in the body. Recent studies have shown that methionine restriction（MetR）in the diet can lead to many physiological reactions,such as prolonging life span,preventing metabolic diseases and participating in the regulation of inflammatory diseases. As an important indicator for evaluating the health of the body,oxidative stress has received more and more attention. Many studies have confirmed the positive effects of MetR on oxidative stress. MetR can participate in the regulation of oxidative stress by reducing the production of mitochondrial reactive oxygen,regulating key signaling pathways and changing expressions of miRNAs,which has a wide range of effects on the health of livestock and poultry. This paper summarizes the effect of MetR on oxidative stress in livestock and poultry,and expounds the discovered molecular mechanism of MetR and oxidative stress.

Key words: methionine restriction, oxidative stress, mitochondrial reactive oxygen species, Nrf2

LIU Rong, CUI Kai, BAI Fu-heng, DIAO Qi-yu. Research Progress on Methionine Regulating the Oxidative Stress of Livestock and Poultry[J]. Biotechnology Bulletin, 2020, 36(10): 207-214.

Figures/Tables 2

References 48

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动物、MetR量、处理时间	组织	mtROS	呼吸复合物浓度变化	自由基泄露	氧化损伤标记物	线粒体耗氧量	参考文献
大鼠 80%MetR 6-7周	肝脏	↓ Ⅰ、Ⅲ中	Ⅰ、Ⅳ ↓	↓ Ⅰ、Ⅲ中	↓	↑	[6]
	心脏	↓ Ⅰ中	Ⅰ、Ⅳ ↓	↓ Ⅰ中	↓	↑
大鼠 40%MetR 6-7周	肝脏	↓ Ⅰ、Ⅲ中	Ⅰ、Ⅱ、Ⅲ、Ⅳ ↓	↓ Ⅰ中	↓	-	[24]
大鼠 80%MetR 6-7周	肝脏	↓ Ⅰ、Ⅲ中	Ⅰ、Ⅱ、Ⅲ、Ⅳ ↓	↓ Ⅰ中	↓	-	[24]
大鼠 40%MetR 6-7周	心脏	↓ Ⅰ中	Ⅰ、Ⅱ、Ⅲ、Ⅳ -	U	↓	-	[25]
仔猪 30%MetR 2周	肝脏	↓ Ⅰ中	Ⅰ ↓	↓ Ⅰ中	↓	↑	[26]
虹鳟 56%MetR 6周	肝脏	U	Ⅰ、Ⅱ、Ⅳ ↓	U	↓	U	[27]

动物、MetR量、处理时间	组织	mtROS	呼吸复合物浓度变化	自由基泄露	氧化损伤标记物	线粒体耗氧量	参考文献
大鼠 80%MetR 6-7周	肝脏	↓ Ⅰ、Ⅲ中	Ⅰ、Ⅳ ↓	↓ Ⅰ、Ⅲ中	↓	↑	[6]
	心脏	↓ Ⅰ中	Ⅰ、Ⅳ ↓	↓ Ⅰ中	↓	↑
大鼠 40%MetR 6-7周	肝脏	↓ Ⅰ、Ⅲ中	Ⅰ、Ⅱ、Ⅲ、Ⅳ ↓	↓ Ⅰ中	↓	-	[24]
大鼠 80%MetR 6-7周	肝脏	↓ Ⅰ、Ⅲ中	Ⅰ、Ⅱ、Ⅲ、Ⅳ ↓	↓ Ⅰ中	↓	-	[24]
大鼠 40%MetR 6-7周	心脏	↓ Ⅰ中	Ⅰ、Ⅱ、Ⅲ、Ⅳ -	U	↓	-	[25]
仔猪 30%MetR 2周	肝脏	↓ Ⅰ中	Ⅰ ↓	↓ Ⅰ中	↓	↑	[26]
虹鳟 56%MetR 6周	肝脏	U	Ⅰ、Ⅱ、Ⅳ ↓	U	↓	U	[27]