Research Progress in Microbial Ferritin

doi:10.13560/j.cnki.biotech.bull.1985.2021-0419

Abstract

Abstract:

Ferritin（FTN）,an important iron storage protein,is ubiquitous in different microorganisms. Based on the summarized analysis of the structure and function of typical ferritin,it is found that the unique structural characteristics of ferritin plays an important role in the supplement,transport,oxidation,nucleation and storage of iron,and also has a significant impact on various biochemical reactions in organisms. Moreover,the molecular modification of ferritin by genetic engineering technology will expand its application as nanocarrier. The special self-assembly characteristics of ferritin make it a potential carrier for drugs or other substances. Therefore,in order to further explore the characteristics and mechanism of ferritin in microorganisms,the structural characteristics of microbial ferritin,the role and release mechanism of iron,the regulation and storage of iron,the molecular modification of ferritin and its perspectives are systematically summarized in this review.

Key words: ferritin, ferroxidase, biomineralization, cage structure protein, nanoparticles

GAO Qi-yu, XU Guang-cui, CUI Cai-xia, ZHANG Wen-bo. Research Progress in Microbial Ferritin[J]. Biotechnology Bulletin, 2022, 38(1): 269-277.

Figures/Tables 5

Fig.1 Ferritin and iron storage cellular compartments[17]

Fig.2 Structural diagram of Fe2+ oxidation site of bacterial ferritin[18]

Fig.3 Mechanism of ferroxidase center[5]

Fig.4 Redox mechanism of iron in ferritin[28]

Fig.5 Synthesis of nanoparticles inside the ferritin inner cavity[51]

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