Research Progress in cGAS-STING Signaling Pathway in ASFV Antagonizing Host

doi:10.13560/j.cnki.biotech.bull.1985.2023-0681

Abstract

Abstract:

African swine fever virus（ASFV）possesses multiple strategies for escaping host immune responses, making it difficult for the virus to be cleared by the host. The cGAS-STING pathway, which mediates host innate immune response, is critical for fighting ASFV infection. Nevertheless, numerous viral proteins targeting different molecules involving in the cGAS-STING pathway inhibit type I interferon production. The deletion of partial of these ASFV genes using genome editing technology attenuated the virulence of the virus, which provides targets for the development of gene deletion vaccine. In this review, we summarized current knowledge on the viral proteins of ASFV modulating host cGAS-STING signaling pathway and elucidate the mechanism of these proteins escaping cGAS-STING signaling pathway, which may deepen the understanding of ASFV immune evasion strategy and provide theoretical basis for the research of ASFV pathogenic mechanism and vaccine development.

Key words: African swine fever virus, innate immunity, cGAS-STING signaling pathway, immune escape

ZHAO Hong-yuan, LIU Qiang, CHENG Wen-yu. Research Progress in cGAS-STING Signaling Pathway in ASFV Antagonizing Host[J]. Biotechnology Bulletin, 2024, 40(3): 109-117.

Figures/Tables 1

References 47

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