The Research Progress of Protein Acetylation

doi:10.13560/j.cnki.biotech.bull.1985.2015.03.003

Abstract

Abstract: Protein acetylation is a ubiquitous, reversible and highly regulated protein post-translational modification. It mainly occurs in ?-NH₂ of protein lysine residues. Protein acetylation was firstly reported about 50 years ago, and now has been the international research hotspot in the field of protein. Acetylation is catalyzed by lysine acetyltransferases and lysine deacetylases, It was involved in almost every aspects of biological processes, including transcription, stress response, central metabolism and protein synthesis and degradation, etc. In recent years, the detection technology of acetylation, which includes mass spectrometry（MS）and protein chip and so on, has developed rapidly and provides a powerful tool for advanced study of acetylation. Protein acetylation is widely used and mainly plays an important role in metabolic diseases. In addition, histone deacetylase inhibitor（HDACIs）has become the potential agent to treat a variety of diseases such as heart disease, diabetes, and cancer. This review probes and summarizes the study process, function, detecting techniques and applications of the acetylation, and also discusses the future directions as well as the prospects of protein acetylation research.

Key words: protein acetylation, metabolism, HDACIs, lysine acetyltransferase

Lü Binna, Liang Wenxing. The Research Progress of Protein Acetylation[J]. Biotechnology Bulletin, 2015, 31(4): 166-174.

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