Research Progress on the Application of Bioinformatics in Prediction and Molecular Design of Antimicrobial Peptide

Abstract

Abstract: Antimicrobial peptides（AMPs）are being increasingly recognized as novel bioactive peptide with critical research value owing to their activities of anti-bacterium，antivirus and antitumor as well as properties of rapidness，broad-spectrum，and high efficiency. Whereas a crucial issue in AMP drug development is how to seek appropriate approaches for maximally improving the bioactivity and decreasing the toxicity and production cost. Applying bioinformatics tools to predict novel AMP and to carry out the molecular design of natural AMP is the key to solve this problem. The new progress on bioinformatics involved in AMP prediction and optimal design is reviewed. in order to expand the sources of new AMPs and elevate the bioactivities of known AMPs.

Key words: antimicrobial peptides（AMP）, bioinformatics, active peptide prediction, molecular design

CLC Number:

10.13560/j.cnki.biotech.bull.1985.2016.12.005

XIAO Yi-chen,XIONG Hao,XIE Chuan,Lü Nong-hua. Research Progress on the Application of Bioinformatics in Prediction and Molecular Design of Antimicrobial Peptide[J]. Biotechnology Bulletin, 2016, 32(12): 23-28.

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