Biotechnology Bulletin ›› 2022, Vol. 38 ›› Issue (7): 119-127.doi: 10.13560/j.cnki.biotech.bull.1985.2021-1184

Previous Articles     Next Articles

Biosynthesis of Natural Carotenoids:Progress and Perspective

ZHOU Lin1,2(), LIANG Xuan-ming1, ZHAO Lei1,2()   

  1. 1. Tianjin Institute of Industrial Biotechnology,Chinese Academy of Sciences,Tianjin 300308
    2. Key Laboratory of Systems Microbial Biotechnology,Chinese Academy of Sciences,Tianjin 300308
  • Received:2021-09-14 Online:2022-07-26 Published:2022-08-09
  • Contact: ZHAO Lei E-mail:zhoulin@tib.cas.cn;zhaol@tib.cas.cn

Abstract:

Carotenoids are the general term for a large class of natural pigment substances broadly in higher plants,microorganisms and algae,one of important natural pigments groups for food. Cell factories are widely used in the production of various chemicals,food and drugs,and are the central link of green biological manufacturing. It is economically feasible and environmentally friendly to synthesize source-scarce,difficult-to-be-obtained and high value-added natural carotenoids in cell factories. Carotenoids play important roles in anti-oxidation,eye-vision protection and anti-cancer. In the present review,the analysis of carotenoid biosynthesis pathway,the selection and modification of chassis cells,the module assembly and adaptation of pathway,and the strategy of synthetic biology during the construction of cell factory used for carotenoids biosynthesis are introduced in details. Future opportunities and challenges in the industrial production of carotenoids are discussed.

Key words: carotenoids, astaxanthin, β-carotene, lutein, synthetic biology