Research Progress of Nucleic Acid Aptamer Optical Biosensor in Kanamycin Detection

doi:10.13560/j.cnki.biotech.bull.1985.2019-1008

Abstract

Abstract: Kanamycin is an aminoglycoside antibiotic,and it is one of commonly used veterinary drugs in China because of its good effect and low price. However,if kanamycin is used in over-dosage,it will remain in the animal body largely;then,it is enriched into the human body by the food chain;and subsequently,the toxic side effects such as ototoxicity,nephrotoxicity and even death may be caused. Thus quantitative detection of kanamycin is very important. In recent years,a large number of optical methods for detecting kanamycin based on nucleic acid aptamers have been developed to ensure testing requirements. Firstly,the related concepts of nucleic acid aptamers and optical biosensors are clarified. Then,according to their different reaction mechanisms,the optical biosensors are classified,and the basic principles and detection ranges of various sensors are also described. Finally,the advantages,disadvantages and development directions of these sensors are summarized and prospected. The exploration of these methods will provide new technical support for food safety testing.

Key words: kanamycin, nucleic acid aptamer, biosensor, optical method, food safety

WU Ya, XU Zhi-hui, ZHANG Biao, ZHAO Dong-fang, CAO Wen-xin, ZHANG Xing-ping. Research Progress of Nucleic Acid Aptamer Optical Biosensor in Kanamycin Detection[J]. Biotechnology Bulletin, 2020, 36(1): 193-201.

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