Biotechnology Bulletin ›› 2013, Vol. 0 ›› Issue (2): 15-21.

• Research report • Previous Articles     Next Articles

Application of Zebrafish in Research of Transgenic Organisms

Liu Lili Wang Jian Wu Wei Wang Haisheng Yan Yanchun   

  1. (Graduate School of Chinese Academy of Agracultural Sciences,Beijing 100081)
  • Received:2012-07-20 Revised:2013-02-27 Online:2013-02-26 Published:2013-02-27
  • Contact: 闫艳春,女,博士,教授,研究方向:微生物分子生物学与基因工程;E-mail :yanyanchun@caas.net.cn

Abstract: The recent explosion of transgenic zebrafish lines in the literature demonstrates the value of this model system for detailed in vivo analysis of gene regulation, development and differentiation and morphogenetic movements, as well as drug screening and environment monitoring. After an outline of the application and development history of vital models from Escherichia coli to Musmusculus, the superiority of zebrafish as a model organism will be emphasized. Then this article will review the development history of transgenic technology in zebrafish and the uses of transgenic zebrafish. And finally problems in future development of transgenic zebrafish will be presented.

Key words: Model organism, Zebrafish, Danio rerio, Transgenic animal, Application