超长链单不饱和脂肪酸的生物合成和代谢工程

doi:10.13560/j.cnki.biotech.bull.1985.2015.12.006

摘要/Abstract

摘要： 超长链单不饱和脂肪酸(Very long chain monounsaturated fatty acid，VLCMFA)是指主碳链上碳原子数大于或等于20，有且只有一个不饱和双键的脂肪酸。VLCMFA较多的存在于各种油料植物及少数微藻中，目前发现的有鳕油酸(C20:1)、芥酸(C22:1)、神经酸(C24:1)和西门木烯酸(C26:1)。VLCMFA具有独特的工业用途和潜在药用保健功效。主要综述VLCMFA的生物合成和代谢工程研究进展，旨为应用开发提供参考。

关键词: 脂肪酸, 超长链单不饱和脂肪酸, 芥酸, 神经酸, 代谢工程

Abstract: Very long-chain monounsaturated fatty acids(VLCMFA)are fatty acids with aliphatic tail of≥ 20 carbons and a sole unsaturated double bond. VLCMFA has been discovered in a variety of plants and a few of microalgae. Up to now, four VLCMFAs have been identified, they are gadoleic acid(C20:1), erucic acid(C22:1), nervonic acid(C24:1), and ximenic acid(C26:1). VLCMFA shows great potentials in pharmaceutical and chemical industries. This review focuses on the research progress on biosynthesis and metabolic engineering of VLCMFA, which aims at providing the reference for its applications.

Key words: fatty acid, very long-chain monounsaturated fatty acid, erucic acid, nervonic acid, metabolic engineering

田德雨,王士安,王立昊,王家林,李福利. 超长链单不饱和脂肪酸的生物合成和代谢工程[J]. 生物技术通报, 2015, 31(12): 42-49.

Tian Deyu, Wang Shian, Wang Lihao, Wang Jialin, Li Fuli. The Biosynthesis and Metabolic Engineering of Very Long-chain Monounsaturated Fatty Acid[J]. Biotechnology Bulletin, 2015, 31(12): 42-49.

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