生物技术通报 ›› 2021, Vol. 37 ›› Issue (2): 203-215.doi: 10.13560/j.cnki.biotech.bull.1985.2020-0340

• 综述与专论 • 上一篇    下一篇

RNA药物的发展及其在水产上的应用

潘银来1,2(), 邱春辉1,3, 王艺磊1,4, 张子平1,2,5()   

  1. 1.大黄鱼育种国家重点实验室,宁德 352103
    2.福建农林大学动物科学学院,福州 350001
    3.福建农林大学生命科学学院,福州 350001
    4.集美大学水产学院,厦门 361021
    5.福建农林大学海洋研究院 福建省海洋生物技术重点实验室,福州 350001
  • 收稿日期:2020-03-25 出版日期:2021-02-26 发布日期:2021-02-26
  • 作者简介:潘银来,男,硕士研究生,研究方向:水产疫苗;E-mail: 925441002@qq.com
  • 基金资助:
    大黄鱼育种国家重点实验室项目(LYC2018RS05);福建省科技厅项目(2017N5002);福州市科技局项目(2018-G-43);福建省教育厅项目(JT180135);“十三五计划”福州海洋经济创新发展示范城市项目(2019-FZHJ17);福建省海洋与渔业局项目(ZHHY-2019-3)

Development of RNA Drugs and Its Application in Aquaculture

PAN Yin-lai1,2(), QIU Chun-hui1,3, WANG Yi-lei1,4, ZHANG Zi-ping1,2,5()   

  1. 1. State Key Laboratory of Large Yellow Croaker Breeding,Ningde 352103
    2. College of Animal Sciences,Fujian Agriculture and Forestry University,Fuzhou 350001
    3. College of Life Sciences,Fujian Agriculture and Forestry University,Fuzhou 350001
    4. Fisheries College,Jimei University,Xiamen 361021
    5. Key Laboratory of Marine Biotechnology of Fujian Province,Institute of Oceanology,Fujian Agriculture and Forestry University,Fuzhou 350002
  • Received:2020-03-25 Published:2021-02-26 Online:2021-02-26

摘要:

基于RNA的RNA干扰和基因组编辑技术被应用于许多领域。由于其作用的特异性,使RNA成为靶点药物的候选分子。基于RNA的疾病治疗药物的研发近年来有了迅速的发展。随着养殖业的发展,病害引起的损失日益严重。运用小分子RNA药物有效保护水产动物抵抗病毒、寄生虫等的危害的研究也取得了一些成果。综述了RNA干扰和CRISPR的作用机制、原理及其在抑制水产动物病毒等方面的最新发展和应用,并结合我们的研究成果进行阐述,同时对目前相关的RNA药物进行总结,旨为今后更好地研究水产动物的RNA药物提供参考。

关键词: 水产动物疾病, CRISPR, RNA干扰, RNA药物

Abstract:

RNA-based RNA interference and genome editing technologies are used in many fields. Because of its specificity,RNA becomes a candidate molecule for the development of target drugs. The research and development of RNA-based disease treatment drugs have been developing rapidly in recent years. With the development of the aquaculture industry,the losses caused by the diseases have become more and more serious. Studies on using small-molecule RNA drugs to effectively protect aquatic animals against viruses and parasites have also achieved some results. In this review,we summarized the mechanism and principle of RNA interference and CRISPR as well as the latest developments and applications in inhibiting aquatic animal viruses combined with our research results,and the current related RNA drugs are summarized,aiming for providing references for future research on the development of RNA drugs in aquatic animals.

Key words: aquatic animal disease, CRISPR, RNA interference, RNA drugs