生物技术通报 ›› 2021, Vol. 37 ›› Issue (1): 123-136.doi: 10.13560/j.cnki.biotech.bull.1985.2020-1409
黄小丹1(), 陈梦雨1,2, 黄文洁2, 张名位3(), 晏石娟1,2()
收稿日期:
2020-11-19
出版日期:
2021-01-26
发布日期:
2021-01-15
作者简介:
黄小丹,女,博士,讲师,研究方向:膳食营养与肠道微生物;E-mail: 基金资助:
HUANG Xiao-dan1(), CHEN Meng-yu1,2, HUANG Wen-jie2, ZHANG Ming-wei3(), YAN Shi-juan1,2()
Received:
2020-11-19
Published:
2021-01-26
Online:
2021-01-15
摘要:
综述了植物多酚的分类和来源、在代谢组学技术的驱动下,新型多酚物质的鉴定、控制植物多酚合成途径的关键因子以及多酚的功能特性的研究进展,阐述了植物多酚在肠道中的代谢以及其作为“益生元”调节肠道微生态并影响机体健康的重要功能。目前的研究表明不同植物多酚在调节肠道微生态方面存在差异,多数有促进肠道有益菌作用,并通过与肠道微生物“互作”发挥促进健康效应。总之,植物多酚作为“益生元”影响人体健康可能离不开肠道微生物的介导。各个植物多酚的益生功能也需要进一步阐析,在此过程中需要考虑宿主,膳食等混杂因素的综合影响,且需要拓展临床应用方面的研究。
黄小丹, 陈梦雨, 黄文洁, 张名位, 晏石娟. 基于代谢组学的植物多酚及其肠道健康效应研究进展[J]. 生物技术通报, 2021, 37(1): 123-136.
HUANG Xiao-dan, CHEN Meng-yu, HUANG Wen-jie, ZHANG Ming-wei, YAN Shi-juan. Progress Based on Metabolomics:Plant Polyphenols and Their Gut Health Benefit[J]. Biotechnology Bulletin, 2021, 37(1): 123-136.
多酚类物质/来源 | 实验模型 | 对肠道微生态的影响 | 参考文献 | ||
---|---|---|---|---|---|
多酚化合物 | 黄酮类 | 槲皮素 | 小鼠 (结肠炎) | 与病例对照相比 (1)菌群的α多样性增加; (2)厚壁菌门(Firmicutes)的相对丰度增加。 | [111] |
花青素 | 大鼠 (结直肠癌) | 与病例对照相比 (1)梭菌科(Clostridiaceae)相对丰度增加; (2)科水平上,脱硫弧菌科(Desulfovibrionaceae),肠杆菌科(Enterobacteriaceae)相对丰度降低;属水平上,沃氏嗜胆菌(Bilophila wadsworthia)相对丰度降低。 | [112] | ||
儿茶素/表儿茶素 | 体外模拟 | (1)儿茶素:抑制溶组织梭状芽胞杆菌(Clostridium histolyticum);促进拟球梭菌(Clostridium coccoides/Eubacterium rectale group)、双歧杆菌(Bifidobacterium)和大肠杆菌(Escherichia coli); (2)表儿茶素:促进拟球梭菌(Clostridium coccoides/Eubacterium rectale group)。 | [91] | ||
芪类 | 白藜芦醇 | 小鼠 (结肠炎) | 与病例对照相比 (1)嗜粘蛋白-艾克曼菌(Akkermansia muciniphila)和活泼瘤胃球菌(Ruminococcus gnavus)相对丰度增加; (2)产酸拟杆菌(Bacteroide sacidifaciens)相对丰度降低。 | [113] | |
酚酸 | 绿原酸 | 小鼠 | (1)厚壁菌门(Firmicutes)对拟杆菌门的比例增加; (2)疣微菌门(Verrucomicrobia)和艾克曼菌(Akkermansia)相对丰度增加。 | [114] | |
丹酚酸A | 大鼠 | (1)艾克曼菌(Akkermansia)、芽孢杆菌属(Bacillus)、Blautia属、乳杆菌属(Lactobacillus)和Lachnoclostridium的相对丰度增加; (2)拟杆菌属(Bacteroides)、罗氏菌属(Roseburia)、瘤胃梭菌属(Ruminiclostridium)相对丰度降低。 | [92] | ||
植物提取物 | 茶 | 红茶 | 体外模拟 | (1)促进嗜粘蛋白-艾克曼菌(Akkermansia muciniphila)、克雷伯氏菌属(Klebsiella)和肠球菌(Enterococci); (2)抑制了食物谷菌属(Victivallis)和Blautia coccoides菌。 | [115] |
绿茶 | 人群 (N=12) | (1)在科水平上,毛螺旋菌科(Lachnospiraceae)和双歧杆菌科(Bifidobactericeae)相对丰度增加; (2)在属水平上,双歧杆菌属(Bifidobacterium)、罗氏菌属(Roseburia)、Feacalibacterium属、Eubacterium属、Blautia属、Coprococcus属和Dorea属相对丰度增加。 | [103] | ||
普洱茶 | 小鼠+人群(N=13) | (1)小鼠:芽孢杆菌纲(Bacilli)和α-变形菌纲(α-Proteobacteria)相对丰度降低,拟杆菌纲(Bacteroidia)相对丰度增加; (2)人群:芽孢杆菌纲(Bacilli)和 梭菌纲(Clostridia)相对丰度降低。 | [116] | ||
水果 | 蓝莓 | 大鼠 | 双歧杆菌属(Bifidobacterium)和乳杆菌属(Lactobacillus)相对丰度增加。 | [106] | |
葡萄 | 人群(N=9) | 双歧杆菌(Bifidobacteria)相对丰度增加。 | [117] | ||
石榴 | 人群,RCT(N=50) | 拟杆菌属(Bacteroides)、Gordonibacter和大肠杆菌(Escherichia coli)相对丰度增加。 | [118] | ||
野樱莓 | 大鼠 | (1)厚壁菌门/拟杆菌门(F/B)比值降低; (2)拟杆菌属(Bacteroides)、普雷沃菌属(Prevotella)和Akkermansia属相对丰度增加。 | [119] | ||
猕猴桃 | 人群,RCT (N=28) | 瘤胃球菌科(Ruminococcaceae)、Dorea属和Akkermansia 属相对丰度增加。 | [120] | ||
豆类 | 全芸豆 | 大鼠 | (1)放线菌门(Actinobacteria)相对丰度增加; (2)瘤胃球菌属(Ruminococcus)相对丰度增加。 | [121] | |
可可 | 可可 | 人群,RCT(N=22) | (1)促进双歧杆菌属(Bifidobacterium)、乳杆菌属(Lactobacillus)和肠球菌属(Enterococcus); (2)抑制溶组织梭状芽胞杆菌(Clostridium histolyticum) | [108] |
表1 多酚以及富含多酚的植物提取物对肠道菌群的影响
多酚类物质/来源 | 实验模型 | 对肠道微生态的影响 | 参考文献 | ||
---|---|---|---|---|---|
多酚化合物 | 黄酮类 | 槲皮素 | 小鼠 (结肠炎) | 与病例对照相比 (1)菌群的α多样性增加; (2)厚壁菌门(Firmicutes)的相对丰度增加。 | [111] |
花青素 | 大鼠 (结直肠癌) | 与病例对照相比 (1)梭菌科(Clostridiaceae)相对丰度增加; (2)科水平上,脱硫弧菌科(Desulfovibrionaceae),肠杆菌科(Enterobacteriaceae)相对丰度降低;属水平上,沃氏嗜胆菌(Bilophila wadsworthia)相对丰度降低。 | [112] | ||
儿茶素/表儿茶素 | 体外模拟 | (1)儿茶素:抑制溶组织梭状芽胞杆菌(Clostridium histolyticum);促进拟球梭菌(Clostridium coccoides/Eubacterium rectale group)、双歧杆菌(Bifidobacterium)和大肠杆菌(Escherichia coli); (2)表儿茶素:促进拟球梭菌(Clostridium coccoides/Eubacterium rectale group)。 | [91] | ||
芪类 | 白藜芦醇 | 小鼠 (结肠炎) | 与病例对照相比 (1)嗜粘蛋白-艾克曼菌(Akkermansia muciniphila)和活泼瘤胃球菌(Ruminococcus gnavus)相对丰度增加; (2)产酸拟杆菌(Bacteroide sacidifaciens)相对丰度降低。 | [113] | |
酚酸 | 绿原酸 | 小鼠 | (1)厚壁菌门(Firmicutes)对拟杆菌门的比例增加; (2)疣微菌门(Verrucomicrobia)和艾克曼菌(Akkermansia)相对丰度增加。 | [114] | |
丹酚酸A | 大鼠 | (1)艾克曼菌(Akkermansia)、芽孢杆菌属(Bacillus)、Blautia属、乳杆菌属(Lactobacillus)和Lachnoclostridium的相对丰度增加; (2)拟杆菌属(Bacteroides)、罗氏菌属(Roseburia)、瘤胃梭菌属(Ruminiclostridium)相对丰度降低。 | [92] | ||
植物提取物 | 茶 | 红茶 | 体外模拟 | (1)促进嗜粘蛋白-艾克曼菌(Akkermansia muciniphila)、克雷伯氏菌属(Klebsiella)和肠球菌(Enterococci); (2)抑制了食物谷菌属(Victivallis)和Blautia coccoides菌。 | [115] |
绿茶 | 人群 (N=12) | (1)在科水平上,毛螺旋菌科(Lachnospiraceae)和双歧杆菌科(Bifidobactericeae)相对丰度增加; (2)在属水平上,双歧杆菌属(Bifidobacterium)、罗氏菌属(Roseburia)、Feacalibacterium属、Eubacterium属、Blautia属、Coprococcus属和Dorea属相对丰度增加。 | [103] | ||
普洱茶 | 小鼠+人群(N=13) | (1)小鼠:芽孢杆菌纲(Bacilli)和α-变形菌纲(α-Proteobacteria)相对丰度降低,拟杆菌纲(Bacteroidia)相对丰度增加; (2)人群:芽孢杆菌纲(Bacilli)和 梭菌纲(Clostridia)相对丰度降低。 | [116] | ||
水果 | 蓝莓 | 大鼠 | 双歧杆菌属(Bifidobacterium)和乳杆菌属(Lactobacillus)相对丰度增加。 | [106] | |
葡萄 | 人群(N=9) | 双歧杆菌(Bifidobacteria)相对丰度增加。 | [117] | ||
石榴 | 人群,RCT(N=50) | 拟杆菌属(Bacteroides)、Gordonibacter和大肠杆菌(Escherichia coli)相对丰度增加。 | [118] | ||
野樱莓 | 大鼠 | (1)厚壁菌门/拟杆菌门(F/B)比值降低; (2)拟杆菌属(Bacteroides)、普雷沃菌属(Prevotella)和Akkermansia属相对丰度增加。 | [119] | ||
猕猴桃 | 人群,RCT (N=28) | 瘤胃球菌科(Ruminococcaceae)、Dorea属和Akkermansia 属相对丰度增加。 | [120] | ||
豆类 | 全芸豆 | 大鼠 | (1)放线菌门(Actinobacteria)相对丰度增加; (2)瘤胃球菌属(Ruminococcus)相对丰度增加。 | [121] | |
可可 | 可可 | 人群,RCT(N=22) | (1)促进双歧杆菌属(Bifidobacterium)、乳杆菌属(Lactobacillus)和肠球菌属(Enterococcus); (2)抑制溶组织梭状芽胞杆菌(Clostridium histolyticum) | [108] |
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