Research Progress on Mesoporous Silica Mediated Functional Nucleic Acids-based Detection Technologies

doi:10.13560/j.cnki.biotech.bull.1985.2017-1075

Abstract

Abstract: Mesoporous silica nanoparticles（MSNs）are porous inorganic nanoparticles,they are characterized by adjustable particle and pore size,large surface area and pore volume,surface modification and fine biological compatibility and others,and are widely used as a delivery carrier for anticancer drug in medical field. At present,MSNs and functional nucleic acids（FNA）are combined to prepare biosensors for building detection technologies,the study of which is mainly focused on the FNA immobilization on the surface of MSNs. Through the change of FNA structure,the controlled release of guest molecules in mesopores can be realized and further converted into fluorescent signals,electrical signals,and the like for detection. Here we reviewed the basic properties,preparation and applications of MSNs,highlighted several types of functional nucleic acid biosensors based on MSNs,and discussed the practical significances and issues while applying mesoporous silica mediated functional nucleic acids-based detection technologies. Finally,we prospected this technology and the potential opportunities and challenges,aiming at further promoting the practical application of mesoporous silica mediated functional nucleic acids-based detection technologies.

Key words: mesoporous silica, functional nucleic acids, biosensor, nanomaterials, bioimaging

LI Shu-ting, HE Wan-chong, HUANG Kun-lun, XU Wen-tao. Research Progress on Mesoporous Silica Mediated Functional Nucleic Acids-based Detection Technologies[J]. Biotechnology Bulletin, 2018, 34(9): 139-148.

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