Research Progress on Metal-organic Framework-mediated Functional Nucleic Acid Detection Technology

doi:10.13560/j.cnki.biotech.bull.1985.2018-0055

Abstract

Abstract: Metal-Organic Frameworks（MOFs）are also known as Coordination Polymers（CPs）. They are crystalline molecular functional material that are composed of metal ions or metal clusters and organic ligands and formed under relatively mild conditions. It has the characteristics of high porosity,excellent structural adjustability,huge internal surface area,structural diversity,high chemical stability and strong thermal stability. It has been used in various fields such as chemical engineering and medicine. At present,the research on the combination of MOFs and Functional Nucleic Acids（FNA）in the field of detection technology mainly focuses on two kinds of fluorescence biosensors and electrochemical biosensors,and other types of biosensors have rarely been reported. In addition,the preparation of MOFs has also become increasingly miniaturized to improve its performance. In this paper,the recent progress on MOFs-mediated functional nucleic acid biosensors is reviewed. The practical significance and problems of MOFs-mediated functional nucleic acid detection technology in applied research are discussed. The prospects for the development of the technology,the opportunities and challenges it may face are prospected,and it is aimed that it will further promote the practical application of the MOFs-mediated functional nucleic acid detection technology.

Key words: metal-organic framework, functional nucleic acid, biosensor, biological imaging

LI Shu-ting, HE Wan-chong, XU Wen-tao. Research Progress on Metal-organic Framework-mediated Functional Nucleic Acid Detection Technology[J]. Biotechnology Bulletin, 2018, 34(9): 129-138.

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