Advances in Biosensors Based on Triplex Nucleic Acids

doi:10.13560/j.cnki.biotech.bull.1985.2018-0381

Abstract

Abstract: A super-molecular nucleic acid assembly,termed Triplex Nucleic Acids（TNAs）,is formed between the third oligonucleotide strand and classical Waston-Crick base-pair-formed double strands through the non-classical Hoogsteen hydrogen bond at the major groove site. Among recently developed biosensors,TNAs-based sensing platforms have been attracting more attentions on account of the advantages of rapidity,simplicity,sensitivity,and reversibility. In this review,we generalized and exemplified different TNAs-based biosensors from their classifications,characteristics to applications. We also highlighted the development prospects of the TNAs biosensor.

Key words: triplex nucleic acid（TNAs）, biosensor, comment

TIAN Jing-jing, LUO Yun-bo, XU Wen-tao. Advances in Biosensors Based on Triplex Nucleic Acids[J]. Biotechnology Bulletin, 2018, 34(9): 15-28.

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