Circular RNAs：Research Progress and Its Significance in Birds and Livestock

doi:10.13560/j.cnki.biotech.bull.1985.2018-0403

Abstract

Abstract: Circular RNAs（circRNAs）are a kind of newly discovered endogenous non-coding RNA molecule with covalently-formed closed loop structure. They are expressed abundantly in eukaryotic organisms,mainly from exons and/or introns,and have several traits,such as rich variety,high conservation,high specificity in cell and tissue,high stability,etc. The current studies show that the formation of circRNA is induced by lariat-driven circularization and intron pairing-driven circularization and regulated by varieties of cis and trans original. circRNA exerts their biological functions in numerous ways,such as combining with RNA binding proteins and then regulating the gene expression and protein translation,combining with miRNAs to play miRNA sponges function,and translating functional proteins or peptides by open reading frame in circRNAs and taking part in signal transcription among cells. The economic characters and disease control and prevention are the concerns of animal husbandry. The studies reveal that circRNAs play an important role in various physiological functions including livestock diseases control and prevention,breeding and reproducing,fat deposition,muscle and neural development,which have important research value in economic properties such as meat and dairy production and quality of livestock as well as disease control and prevention. This review summarized the characteristics,formation mechanism,main biological function of circRNA and research progresses of it in livestock and poultry species,aiming at providing certain theoretical basis and reference for the studies of livestock,providing new insights for the development of new molecular genetic markers,and providing novel techniques for enriching livestock and poultry breeding.

Key words: circular RNA, livestock and poultry, molecule character, formation mechanism, biological function

XU Hai-dong, LENG Qi-ying, PATRICIA Adu-Asiamah, WANG Zhang, LI Ting, ZHANG Li. Circular RNAs：Research Progress and Its Significance in Birds and Livestock[J]. Biotechnology Bulletin, 2018, 34(11): 56-69.

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