Research Progress in NAD+ Cap Modification at the 5' End of RNA

doi:10.13560/j.cnki.biotech.bull.1985.2021-0975

Abstract

Abstract:

The m7G cap,which has long been considered as a hallmark of eukaryotic mRNAs,protects RNAs from degradation and recruits the machinery for splicing,polyadenylation,nuclear export,and translation. The nucleotide-containing metabolite,nicotinamide adenine dinucleotide（NAD⁺）,has recently been detected at the 5' end of RNAs in several species including prokaryotes as a new cap. Now research on the biological functions of NAD⁺-capped RNAs（NAD-RNAs）is still at the initial stage. This review summarizes the discovery of NAD-RNAs as well as the development of its detection and identification technology,discusses the regulatory functions of the NAD⁺ cap on RNA as well as the factors affecting RNA NAD⁺ capping and decapping,and speculates on the potential functions of NAD-RNAs in growth,development and environmental responses. Finally,we propose future research directions and topics in order to garner attention on the outstanding questions regarding the molecular and biological functions NAD-RNAs.

Key words: RNA cap, NAD⁺, NAD-RNA, post-transcriptional regulation, biological function

DONG Hai-jiao, YANG Xiao-yu, MO Bei-xin, CHEN Xue-mei, CUI Jie. Research Progress in NAD⁺ Cap Modification at the 5' End of RNA[J]. Biotechnology Bulletin, 2022, 38(2): 245-251.

Figures/Tables 1

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