生物技术通报 ›› 2020, Vol. 36 ›› Issue (10): 215-225.doi: 10.13560/j.cnki.biotech.bull.1985.2020-0136

• 综述与专论 • 上一篇    下一篇

核糖体肽生物合成中的典型翻译后修饰研究

汪金秀1,3(), 张琪2, 丁伟4(), 陈拓1()   

  1. 1.中国科学院西北生态环境资源研究院,兰州 730000
    2.复旦大学化学系,上海 200433
    3.中国科学院大学,北京 100049
    4.上海交通大学生命科学技术学院,上海 200030
  • 收稿日期:2020-02-15 出版日期:2020-10-26 发布日期:2020-11-02
  • 作者简介:汪金秀,女,硕士研究生,研究方向:微生物学;E-mail: nwnujinxiu_w@163.com
  • 基金资助:
    国家自然科学青年科学基金项目(31600398);甘肃杰出青年基金项目(17JR5RA308)

Classic Post-translational Modification in Ribosomally Synthesized and Post-translationally Modified Peptides Biosynthesis

WANG Jin-xiu1,3(), ZHANG Qi2, DING Wei4(), CHEN Tuo1()   

  1. 1. Northwest Institute of Eco-Environmental and Resources,Chinese Academy of Sciences,Lanzhou 73000
    2. Fudan University,Shanghai 200433
    3. University of Chinese Academy of Sciences,Beijing 100049
    4. School of Life Sciences and Biotechnology,Shanghai Jiaotong University,Shanghai 200030
  • Received:2020-02-15 Published:2020-10-26 Online:2020-11-02

摘要:

核糖体肽类天然产物(RiPPs)是由核糖体合成,经由翻译后修饰得到的一大类天然产物,具有广泛的结构和生物活性多样性。综述了核糖体肽的类别及种类众多的翻译后修饰机理,探讨了翻译后修饰对结构多样性的意义,并对生物信息学背景下利用基因组挖掘技术来开发更多RiPPs做了展望。

关键词: 核糖体肽, 后修饰, 生物合成途径, 基因组挖掘

Abstract:

Ribosomally synthesized and post-translationally modified peptides(RiPPs)are a large class of natural products synthesized by ribosome via post-translational modification which feature a wide range of structural and biological diversity. We reviewed the various classes of RiPPs and their post-translationally modification mechanisms,discussed the significance of post-translational modifications,and prospected the development of RiPPs using genome mining under bioinformatics.

Key words: RiPPs, post-modification, biosynthetic pathway, genome mining