Research Progress in Gut Microbiota and Metabolites Regulating Host Intestinal Immunity

doi:10.13560/j.cnki.biotech.bull.1985.2022-1530

Abstract

Abstract:

The gut microbiota is a stable and complex microecosystem. After a long period of evolution, these microorganisms have established a stable symbiotic relationship with the host. The activity of the microorganism directly affects the health of the host. They not only play an important role in digestion and metabolism of host nutrients and body development, but also are closely related to host immunity and disease. The interaction mechanism between the gut microbiota and the body's immune system is very complex, and it has not yet been fully elucidated by various environmental factors. Microbial metabolites and microbial-body co-metabolites play an important role in regulating immune function, which gradually attract researchers’ attention. Therefore, on the basis of introducing the intestine and its role in host defense, this article reviews how intestinal microbes and metabolites in the intestine promote the development of the host's immune system and regulate the host's immune response. The purpose is to provide a reference for further research on the interaction between gut microbiota and metabolites and the body's immune system, and concurrently to provide a theoretical basis for nutritional measures to improve the intestinal health of livestock and poultry.

Key words: gut microbiota, metabolites, intestinal barrier, intestinal mucosal immunity

SHA Shan-shan, DONG Shi-rong, YANG Yu-ju. Research Progress in Gut Microbiota and Metabolites Regulating Host Intestinal Immunity[J]. Biotechnology Bulletin, 2023, 39(8): 126-136.

Figures/Tables 1

References 71

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