Research Progress on Mesoporous Silica in Drug Delivery System and in vitro/in vivo

doi:10.13560/j.cnki.biotech.bull.1985.2019-0481

Abstract

Abstract: Mesoporous silica nanoparticles are widely concerned in biomedical field in recent years due to their specific characteristics,including large specific surface area,high porosity,adjustable mesoporous structure and easy surface modification. As a novel carrier,mesoporous silica can not only improve the solubility of poorly soluble drugs and effectively improve the bioavailability of drugs,but achieve the targeting of tumor cells by modifying or coating functional substances and control the adsorption and release of drug. Its stable framework structure can deliver and protect nucleic acid molecules for gene therapy purposes. However,in the application of mesoporous silica nanoparticles to the clinic,further work is needed to predict and assess potential toxicity and adverse reactions,to clarify their absorption,distribution,metabolism,excretion,biocompatibility and toxicity in vivo for ensuring their availability and safety in patients. This paper reviews the application of mesoporous silica nanoparticles in drug delivery system and gene therapy,mainly focuses on the research results on targeted and stimuli-responsive mesoporous silica,as well as deeply summarizes the pharmacokinetics,biocompatibility and toxicity of mesoporous silica,aiming at providing a reference for the application of mesoporous silica in biomedicine.

Key words: mesoporous silica, drug delivery system, gene therapy, pharmacokinetics, biocompatibility, toxicity

ZHANG Wen-jun, WU Meng-ting, LÜ Chun-yan, WANG Qing, CHEN Yong-lin. Research Progress on Mesoporous Silica in Drug Delivery System and in vitro/in vivo[J]. Biotechnology Bulletin, 2019, 35(12): 159-168.

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