Research Progress and Prospects of Adiponectin and Its Receptor in Mammal

doi:10.13560/j.cnki.biotech.bull.1985.2019-0829

Abstract

Abstract: As an endogenous cytokine secreted from adipose tissue,adiponectin plays an importantly biological role in regulating energy homeostasis,glucose metabolism,fatty acid oxidation,anti-inflammatory,and development of insulin resistance via its receptor’s effects. In order to provide some theory basis and new ideas for molecular breeding in mammal. This review focuses on the structural characteristics,expression regulation and polymorphism of adiponectin and its receptors,on how to improve mammal’s growth and reproductive performance,and on how to reduce fat deposition in mammals and so on.

Key words: adiponectin, adiponectin receptor, expression regulation, polymorphism

ZHANG De-rong, MA Xiao-xia, LI Yu-fei, ZHAO Yong-qing, HUO Sheng-dong, MA Zhong-ren, BAI Jia-lin. Research Progress and Prospects of Adiponectin and Its Receptor in Mammal[J]. Biotechnology Bulletin, 2020, 36(6): 236-244.

References

[1] Balsan GA, Vieira JL, Oliveira AM, et al.Relationship between adiponectin, obesity and insulin resistance[J]. Revista da Associacao Medica Brasileira, 2015, 61(1):72-80.
[2] Katsiki N, Mantzoros C, Mikhailidis DP.Adiponectin, lipids and atherosclerosis[J]. Current Opinion in Lipidology, 2017, 28(4):347-354.
[3] Achari AE, Jain SK. Adiponectin, a therapeutic target for obesity, diabetes,endothelial dysfunction[J]. International Journal of Molecular Sciences, 2017, 18(6):pii:E1321.
[4] Scherer PE, Williams S, Fogliano M, et al.A novel serum protein similar to C1q, produced exclusively in adipocytes[J]. The Journal of Biological Chemistry, 1995, 270(45):26746-26749.
[5] Hu E, Liang P, Spiegelman BM.AdipoQ is a novel adipose-specific gene dysregulated in obesity[J]. The Journal of Biological Chemistry, 1996, 271(18):10697-10703.
[6] Maeda K, Okubo K, Shimomura I, et al.cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1(AdiPose Most abundant Gene transcript 1)[J]. Biochemical and Biophysical Research Communications, 1996, 221(2):286-289.
[7] Nakano Y, Tobe T, Choi-Miura NH, et al.Isolation and characterization of GBP28, a novel gelatin-binding protein purified from human plasma[J]. The Journal of Biological Chemistry, 1996, 120(4):803-812.
[8] Arita Y, Kihara S, Ouchi N, et al.Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity[J]. Biochemical and Biophysical Research Communications, 1999, 257(1):79-83.
[9] Pajvani UB, Du X, Combs TP, et al.Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications fpr metabolic regulation and bioactivity[J]. The Journal of Biological Chemistry, 2003, 278(11):9073-9085.
[10] Frankenberg ADV, Reis AF, Gerchman F.Relationships between adiponectin levels, the metabolic syndrome, and type 2 diabetes:a literature review[J]. Archives of Endocrinology and Metabolism, 2017, 61(6):614-622.
[11] Fruebis J, Tsao TS, Javorschi S, et al.Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice[J]. Proceedings of the National Academy of Sciences of the United States of America. 2001, 98(4), 2005-2010.
[12] Yamauchi T, Kamon J, Minokoshi Y, et al.Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase[J]. Nature Medicine, 2002, 8(11):1288-1295.
[13] Yamauchi T, Kamon J, Waki H, et al.The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity[J]. Nature Medicine, 2001, 7(8):941-946.
[14] Kadowaki T, Yamauchi T.Adiponectin and adiponectin receptors[J]. Endocrine Reviews, 2005, 26(3):439-451.
[15] Saito K, Tobe T, Minoshima S, et al.Organization of the gene for gelatin-binding protein(GBP28)[J]. Gene, 1999, 229:67-73.
[16] Das K, Lin Y, Widen E, et al.Chromosomal localization, expression pattern, and promoter analysis of the mouse gene encoding adipocyte-specific secretory protein Acrp30[J]. Biochemical and Biophysical Research Communications, 2001, 280(4):1120-1129.
[17] Dai MH, Xia T, Zhang GD, et al.Cloning, expression and chromosome localization of porcine adiponectin and adiponectin receptors genes[J]. Domestic Animal Endocrinology, 2006, 30(2):117-125.
[18] Lemor A, Mielenz M, Altmann M, et al.mRNA abundance of adiponectin and its receptors, leptin and visfatin and of G-protein coupled receptor 41 in five different fat depots from sheep[J]. Journal of Animal Physiology and Animal Nutrition, 2010, 94(5):e96-e101.
[19] Zhang TX, Li WX, Qi L, et al.Adiponectin plays a role in energy metabolism for musk secretion in scent glands of muskrats(Ondatra zibethicus)[J]. Endocrine Journal, 2016, 63(7):633-641.
[20] Shapiro L, Scherer PE.The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor[J]. Current Biology, 1998, 8(6):335-338.
[21] Ghadge AA, Khaire AA, Kuvalekar AA.Adiponectin:A potential therapeutic target for metabolic syndrome[J]. Cytokine & Growth Factor Reviews, 2018, 39:151-158.
[22] Han F, Robert L.Judd. Adiponectin regulation and function[J]. Comprehensive Physiology, 2018, 8(3), doi:https://doi. org/10. 1002/cphy. c170046.
[23] Gamberi T, Magherini F, Modesti A, et al. Adiponectin signaling pathways in liver diseases[J]. Biomedicines, 2018, 6(2):pii:E52.
[24] Min X, Lemon B, Tang J, et al.Crystal structure of a single-chain trimer of human adiponectin globular domain[J]. FEBS Letters, 2012, 586(6):912-917.
[25] Yamauchi T, Kamon J, Ito Y, et al.Cloning of adiponectin receptors that mediate antidiabetic metabolic effects[J]. Nature, 2003, 423(6941):762-769.
[26] Dalamaga M, Christodoulatos GS.Adiponectin as a biomarker linking obesity and adiposopathy to hematologic malignancies[J]. Hormone Molecular Biology and Clinical Investigation, 2015, 23(1):5-20.
[27] Tanabe H, Fujii Y, Okada-Iwabu M, et al.Crystal structures of the human adiponectin receptors[J]. Nature, 2015, 520(7547):312-316.
[28] Tanabe H, Motoyama K, Ikeda M, et al.Expression, purification, crystallization, and preliminary X-ray crystallographic studies of the human adiponectin receptors, AdipoR1 and AdipoR2[J]. Journal of Structural and Functional Genomics, 2015, 16(1):11-23.
[29] Vasiliauskaité-Brooks I, Sounier R, Rochaix P, et al.Structural insights into adiponectin receptors suggest ceramidase activity
[J]. Nature, 2017, 544(7648):120-123.
[30] Holland WL, Xia JY, Johnson JA, et al.Inducible overexpression of adiponectin receptors highlight the roles of adiponectin-induced ceramidase signaling in lipid and glucose homeostasis[J]. Molecular Metabolism, 2017, 6(3):267-275.
[31] Hug C, Wang J, Ahmad NS, et al.T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin[J]. Proceedings of the National Academy of Sciences of the United States of America, 2004, 101(28):10308-10313.
[32] Schraw T, Wang ZV, Halberg N, et al.Plasma adiponectin complexes have distinct biochemical characteristics[J]. Endocrinology, 2008, 149(5):2270-2282.
[33] Parker-Duffen JL, Nakamura K, Silver M, et al.T-cadherin is essential for adiponectin-mediated revascularization[J]. The Journal of Biological Chemistry, 2013, 288(34):24886-24897.
[34] Denzel MS, Scimia MC, Zumstein PM, et al.T-cadherin is critical for adiponectin-mediated cardioprotection in mice[J]. The Journal of Clinical Investigation, 2010, 120(12):4342-4352.
[35] Ebrahimi-Mamaeghani M, Mohammadi S, Arefhosseini SR, et al.Adiponectin as a potential biomarker of vascular disease[J]. Vascular Health and Risk Management, 2015, 11:55-70.
[36] Pal China S, Sanyal S, Chattopadhyay N.Adiponectin signaling and its role in bone metabolism[J]. Cytokine, 2018, 112:116-131.
[37] Liu Z, Xiao T, Peng X, et al.APPLs:More than just adiponectin receptor binding proteins[J]. Cell Signal, 2017, 32:76-84.
[38] Wang ZV, Scherer PE.Adiponectin, the past two decades[J]. Journal of Molecular Cell Biology, 2016, 8(2):93-100.
[39] Ramsay TG, Caperna TJ.Ontogeny of adipokine expression in neonatal pig adipose tissue[J]. Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology, 2009, 152(1):72-78.
[40] Lord E, Ledoux S, Murphy BD, et al.Expression of adiponectin and its receptors in swine[J]. Journal of Animal Science, 2005, 83
(3):565-578.
[41] Jafarikia M, Méthot S, Maignel L, et al.Association of adiponectin and adiponectin receptor genes with sow productivity estimated breeding values[J]. Molecular Biology Reports, 2015, 42(9):1391-1401.
[42] 张长庆, 刘婷, 赵生国, 等. 脂联素基因在荷斯坦公牛不同组织部位的表达差异[J]. 西北农林科技大学学报:自然科学版, 2015, 43(1):31-36.
[43] 沈留红, 江涛, 巫晓峰, 等. 奶牛胎盘脂联素、瘦素、内脂素与犊牛初生重相关性研究[J]. 畜牧兽医学报, 2017, 48(1):185-192.
[44] 李雪梅, 薛科, 仲涛, 等. 藏山羊脂联素基因的克隆与表达分析[J]. 中国畜牧兽医, 2014, 41(6):23-28.
[45] 李鹏, 张辉, 闫峰. 日粮能量水平对延边黄牛肌内脂肪含量与脂联素表达水平的影响[J]. 中国饲料, 2010, 10:21-23.
[46] De Rosa A, Monaco ML, Nigro E, et al.Tissue-specific downregulation of the adiponectin “system”:possible implications for fat accumulation tendency in the pig[J]. Domestic Animal Endocrinology, 2013, 44(3):131-138.
[47] Wang L, Xue K, Wang Y, et al.Molecular and functional characterization of the adiponectin(AdipoQ)gene in goat skeletal muscle satellite cells[J]. Asian-Australasian Journal of Animal Sciences, 2018, 31(8):1088-1097.
[48] 张辉, 李鹏, 闫峰, 等. 不同品种肉牛脂联素表达与肌内脂肪沉积的关系[J]. 黑龙江畜牧兽医, 2010, 1:36-39.
[49] Ding ST, Liu BH, Ko YH.Cloning and expression of porcine adiponectin and adiponectin receptor 1 and 2 genes in pigs[J]. Journal of Animal Science, 2004, 82(11):3162-3174.
[50] Kang KH, Higashino A, Kim HS, et al.Molecular cloning, gene expression, and tissue distribution of adiponectin and its receptors in the Japanese monkey, Macaca fuscata[J]. Journal of Medical Primatology, 2009, 38(2):77-85.
[51] 薛科. 脂联素(AdipoQ)及其受体(AdipoR1/2)对山羊脂肪沉积的作用机制研究[D]. 雅安:四川农业大学, 2014.
[52] 罗军, 赵旺生, 张天颖, 等. 西农萨能奶山羊脂联素受体1基因(AdipoR1)cDNA克隆、表达及功能分析[J]. 农业生物技术学报, 2015, 23(1):80-88.
[53] Oliveira BSP, Costa JAS, Gomes ET, et al.Expression of adiponectin and its receptors(AdipoR1 and AdipoR2)in goat ovary and its effect on oocyte nuclear maturation in vitro[J]. Theriogenology, 2017, 104:127-133.
[54] Kaklamani V, Yi N, Zhang K, et al.Polymorphisms of ADIPOQ and ADIPOR1 and prostate cancer risk[J]. Metabolism:Clinical and Experimental, 2011, 60(9):1234-1243.
[55] Jasinski-Bergner S, Büttner M, Quandt D, et al.Adiponectin and its receptors are differentially expressed in human tissues and cell lines of distinct origin[J]. Obesity Facts, 2017, 10(6):569-583.
[56] Okada-Iwabu M, Iwabu M, Yamauchi T, et al.Structure and function analysis of adiponectin receptors toward development of novel antidiabetic agents promoting healthy longevity[J]. Endocrine Journal, 2018, 65(10):971-977.
[57] 年士艳. 脂联素及其受体基因多态性与冠心病相关性研究进展[J]. 云南医药, 2018(6):541-544.
[58] 杨彦杰, 昝林森, 王洪宝. 秦川牛脂联素基因第2外显子多态性及其与部分产肉性状的相关性[J]. 西北农林科技大学学报:自然科学版, 2009, 37(9):53-58.
[59] 杨磊, 马遇群, 王丹, 等. 和杂牛、西杂牛脂联素基因多态性分析[J]. 吉林农业科技学院学报, 2015, 24(3):18-20.
[60] 刘重旭, 王凭青, 张宝云, 等. 贵州白山羊和古蔺马羊脂联素基因多态性及其与繁殖性能的关联研究[J]. 中国农业科学, 2011, 44(9):1916-1922.
[61] 孙振梅, 陈祥, 龙威海, 等. 贵州地方山羊ADIPOQ基因外显子1和3多态性研究[J]. 基因组学与应用生物学, 2015, 34(3):500-505.
[62] An Q, Zhou H, Hu J, et al. Haplotypes of the ovine adiponectin gene and their association with growth and carcass traits in New Zealand Romney Lambs[J]. Genes, 2017, 8(6):pii:E160.
[63] 曹海洋. 小尾寒羊ADPN和IGF1基因多态性及其遗传效应分析[D]. 泰安:山东农业大学, 2013.
[64] Houde AA, Murphy BD, Mathieu O, et al.Characterization of swine adiponectin and adiponectin receptor polymorphisms and their association with reproductive traits[J]. Animal Genetics, 2008, 39(3):249-257.
[65] 周宁. 猪ADIPOQ和ADIPORs多态性、表达及与产仔性状的关联分析[D]. 合肥:安徽农业大学, 2016.
[66] Fang F, Liu L, Yang Y, et al.The adipokine adiponectin has potent anti-fibrotic effects mediated via adenosine monophosphate-activated protein kinase:novel target for fibrosis therapy[J]. Arthritis Research & Therapy. 2012, 14(5):R229.
[67] Reinke L, Lam AP, Flozak AS, et al.Adiponectin inhibits Wnt co-receptor, Lrp6, phosphorylation and β-catenin signaling[J]. Biochemical and Biophysical Research Communications. 2016, 470(3):606-612.