A two-factor split-plot design method was adopted to conduct UAV foliar spraying in 3 wheat varieties at 4 different concentrations of iron,zinc and selenium,in order to explore their influences on the contents of iron,zinc,selenium and other mineral elements in grains,so as to seek the optimal combination of foliar spraying concentration and wheat varieties. The results showed that the grains’iron,zinc and selenium contents of Zhengmai 0943 significantly increased under medium concentration treatment（2.5% FeSO4·7H2O + 2.5% ZnSO4·7H2O + 0.1% Na2SeO3）. The zinc content in the grains of Bainong AK58 and Zhengyumai 958 significantly increased under different concentration treatments（T1：0.5% FeSO4·7H2O + 0.5% ZnSO4·7H2O+ 0.02% Na2SeO3,T2：2.5% FeSO4·7H2O + 2.5% ZnSO4·7H2O + 0.1% Na2SeO3,T3：5% FeSO4·7H2O + 5% ZnSO4·7H2O + 0.2% Na2SeO3）,while the iron and selenium contents in the grains did not vary significantly under different concentration treatments. There were significant differences in the effects of variety,concentration and interaction on the grains’iron,zinc,and selenium content,and variety was the major factor,and followed by foliar spraying concentration. Foliar spraying of different concentrations of iron,zinc,and selenium mixed micro-fertilizers by UAV demonstrated overall little effect on the P,Ca,Mg,Cu,and Mn contents of 3 wheat varieties. Under this experimental treatment,the contents of iron,zinc and selenium in the wheat grains significantly increased to achieve the purpose of nutritional enhancement. Therefore,it is recommended to plant Bainong AK58 for iron-rich wheat,Bainong AK58 and Zhengmai 0943 for zinc-rich wheat,and Zhengmai 0943 for selenium-rich wheat.
